Formation of 12L-Hydroxyeicosatetraenoic Acid (12-HETE) by Gingival Tissue
- 1 June 1982
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 61 (6) , 761-763
- https://doi.org/10.1177/00220345820610062101
Abstract
Extracts of inflamed human gingival tissue converted exogenous [14C] -arachidonic acid mainly to a non-prostaglandin metabolite. This metabolite was identified as 12-hydroxyeicosatetraenoic acid (12-HETE) by gas-liquid chromatography-mass-spectometry. Endogenous arachidonic acid was also converted to 12-HETE. Significant formation of PGF2α , PGD2, PGI2, Thromboxane B, or 12-HHT could not be detected, but, in occasional experiments, significant conversion of arachidonic acid to PGE2 was found.This publication has 14 references indexed in Scilit:
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