Gastrointestinal Hormones and the Control of Insulin Secretion

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Abstract
The regulation of insulin secretion from the [human, animal] .beta.-cell of the pancreatic islets is complex, including nervous mechanisms, circulating nutrients, possible paracrines, endocrines and the gastrointestinal hormones. The close relationship between the cells of origin of the gastrointestinal hormones and the absorptive sites for nutrients suggests an important role for these peptides in the regulation of insulin secretion. Participation, in the enteroinsular axis, of the established regulatory factors for exocrine function of the gastrointestinal tract was examined. Secretin, gastrin and gastric inhibitory polypeptide were discussed.