The Efficacy of Vitamin D Administration in Aqueous Preparation

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Abstract
The administration of aqueous preparations (aquasterol) of the antirachitic principle to growing white rats maintains or restores an approximately normal histological pattern in the growth area of bones despite severe pathological disturbance induced by a mineral-deficiency diet. Accompanying this morphological restitution there is a maintenance of skeletal ash percentage in the animals receiving medication, provided that the velocity of growth is not out of proportion to the available mineral. Control animals not receiving medication show a progressive diminution in skeletal ash-content despite the fact that the mineral content of the diet is undiminished. Histologically, commencing restoration of the normal pattern can be seen as early as the fourth day of medication; maximum restoration is evident on the ninth day. Continuation of the experiment upon the growing animal results in a progressive skeletal demineralization despite the maintenance of an approximately normal histological structure in the growth area. It is therefore apparent that restitution of the normal morphology in the growth area and replenishment of skeletal mineral depots are two separate though usually closely related phenomena.