Immediate effects of tobramycin on human cochlea and correlation with serum tobramycin levels.
- 29 January 1977
- Vol. 1 (6056) , 259-261
- https://doi.org/10.1136/bmj.1.6056.259
Abstract
Electrocochleography was performed on three patients to monitor the intravenous administration of tobramycin. When peak serum tobramycin levels exceeded 8-10 mug/ml an immediate dramatic reduction in cochlear output was observed, which recovered fully as serum levels fell. The patients had no auditory or vestibular symptoms either during or after treatment.Keywords
This publication has 11 references indexed in Scilit:
- Outer Hair Cell Loss and Alterations in Glycogen Due to Tobramycin SulfateJAMA Otolaryngology–Head & Neck Surgery, 1976
- Observation of Click-Evoked Compound Viii Nerve Responses Before, During, And Over Seven Months After Kanamycin Treatment in the Guinea PigActa Oto-Laryngologica, 1975
- Tobramycin (nebramycin factor 6): in vitro activity against Pseudomonas aeruginosa.1971
- Calcium binding as a property of kanamycin.1971
- Possible effects of various ototoxic drugs upon the ATP‐hydrolyzing system in the stria vascularis and spiral ligament of the guinea pig.The Laryngoscope, 1967
- Oxygen Consumption in Normal and Kanamycin Damaged CochleaeActa Oto-Laryngologica, 1967
- Suppression and restoration of the microphonic output from the lateral line organ after local application of streptomycinLife Sciences, 1964
- Gentamicin Sulfate, New Antibiotic Against Gram-Negative BacilliJAMA, 1964
- MECHANISM OF NEUROMUSCULAR BLOCKADE BY ANTIBIOTICS1963
- THE CURARIFORM ACTION OF STREPTOMYCIN1957