Melanotic Macules in Albright's Syndrome and in Neurofibromatosis

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Abstract
The clinical features of the pigmentation in 27 cases of Albright's syndrome and 19 cases of neurofibromatosis were indistinguishable. Microscopic study of split-skin preparations showed giant pigment granules in malpighian cells or in melanocytes, or in both, in normal skin and in café-au-lait spots of 19 patients with neurofibromatosis but in only one of ten patients with Albright's syndrome. This difference was statistically significant (P= <0.01), suggesting a possible means of differential diagnosis. The increase in pigmentation in the macules was not necessarily connected with an increase in the number of melanocytes.

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