Hypothalamic-pituitary-gonadotropic function in girls with premature thelarche.
Open Access
- 1 December 1980
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 55 (12) , 941-944
- https://doi.org/10.1136/adc.55.12.941
Abstract
Hypothalamic-pituitary-gonadotropic activity was investigated in 9 girls with premature thelarche, and compared with that in 9 healthy girls and 6 girls with true precocious puberty. The gonadotropin stimulation test with luteinising hormone-releasing hormone was used. Girls with premature thelarche showed luteinising hormone response resembling that of normal girls, and follicle-stimulating hormone (FSH) response quite similar to that of girls with precocious puberty. This suggests that in premature thelarche there is a partial activation of the diencephalic-hypophyseal-gonadal axis, which affects FSH only. Premature thelarche therefore, should be considered as one of the disorders due to altered sensitivity of the hypothalamic receptors which regulate sex maturation.This publication has 17 references indexed in Scilit:
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