Bi-Ventricular Axial Micro- Pump: Impact on Blood Cell Integrity

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Abstract
Background and objective: Off-pump coronary artery bypass grafting has stimulated the development of micro-pumps designed to prevent the hemodynamic instability induced by heart luxation for the exposure of target vessels of the posterior wall. Impella (Aachen, Germany) developed micro-pumps with a miniaturized propeller system for both sides of the heart. The aim of this study was to analyze the impact of both pumps working together on blood cell integrity. Materials and methods: Both right and left-sided micro-pumps were implanted in 5 calves (body weight, 72_4Kg) during 3h. Blood samples for hematology and hemolysis parameters were drawn hourly. Results: Both pumps performed well with a flow of 3.6L+/-0.3L during the 3h of the experiment with stable hemodynamic conditions. Mixed venous oxygen saturation was 63.4+/-15.2% at baseline and 63.8+/-16.3% at the end of the experiment (P = ns). Red cell count, LDH and free plasma hemoglobin were 6.7+/-2.1 x 1012/L, 1807+/-437IU/L, and 32+/-9mg/L at baseline vs. 6.1+/-2.1 x 1012/L, 1871+/-410IU/L, and 52+/-9mg/L at the end of the experiment (P = ns for all comparisons). Platelet count exhibited a non-significant drop (872+/-126 vs. 715+/-22 x 109/L). Conclusions: This double pump system based on the Archimed screw principle is hematologically well tolerated under conditions of prolonged cardiac assist.

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