EFFECT OF CORYNEBACTERIUM-LIQUEFACIENS ON A C3HF MOUSE SQUAMOUS-CELL CARCINOMA

  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (9) , 3115-3119
Abstract
The antitumor effect of anaerobic C. liquefaciens was compared with that of specific immunization. Experimental tumors were 4th or 5th generation isotransplants of a NR-Sl squamous cell carcinoma that arose spontaneously in a C3Hf/He female mouse. Specific immunization failed to exhibit an antitumor effect, whereas a single administration of bacterium markedly inhibited the growth of the tumor. This growth inhibition was most effective when C. laquefaciens was administered 2-4 days before transplantation of tumor cells, but marked inhibition was also observed when this agent was administered after transplantation. The inhibitory effect was independent of dose within a range of 0.1-2.0 mg/mouse. A single dose of < 0.05 mg/mouse did not exhibit antitumor effect. Multiple administrations of large doses, if given with short treatment intervals, were no more effective than 1 small dose. Multiple doses given at 14 day intervals resulted in marked growth retardation. The dose of cells that produced 50% tumor takes in C. liquefaciens treated animals was not significantly different from that in nontreated animals, indicating that this bacterium exhibited no lethal effect on the tumor cells studied.

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