METABOLISM OF FREE AND CONJUGATED 17-HYDROXYCORTICOSTEROIDS IN NORMAL SUBJECTS*

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Abstract
INTRODUCTION CONSIDERABLE information concerning the metabolism of the 17-hydroxycorticosteroids (17-OHCS) has accumulated as a result of the introduction of methods for measuring the free material in various body fluids (1). However, a sizable fraction of the total 17-OHCS in the plasma and the major portion of the 17-OHCS in the urine are not measured by these methods because the corticoids are esterified with glucuronic acid. The recent development of methods for the estimation of 17-OHCS conjugated with glucuronic acid (2) has made possible an extension of our knowledge of 17-OHCS metabolism. Techniques for the measurement of free and conjugated 17-OHCS have been employed in our laboratory to study 17-OHCS metabolism in a variety of clinical situations. The results of such studies in normal human subjects arc presented in this communication. These observations will be compared in subsequent papers with observations made in patients with thyroid (3), liver (4) and kidney (5) disease.

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