Evidence for Angiotensin-Stimulated Proximal Tubular Fluid Reabsorption in Normotensive and Hypertensive Rats: Effect of Acute Administration of Captopril

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Abstract
The effects of captopril [a converting enzyme inhibitor] on mean arterial blood pressure and proximal tubular fluid reabsorption (Jv) were examined in anesthetized normotensive rats and in the non-clipped kidneys of 2-kidney, 1-clip Goldblatt hypertensive rats. In the normotensive animals, captopril reduced arterial blood pressure from 121 .+-. SD 9 to 106 .+-. 10 mm Hg and Jv decreased from 3.78 .+-. 0.45-2.57 .+-. 0.58 .times. 10-4 mm3 mm-2 s-1. Captopril had a greater effect on blood pressure in the hypertensive animals (172 .+-. 17 reduced to 133 .+-. 23 mm Hg) although the decrease in Jv from 3.62 .+-. 0.12 to 2.40 .+-. 0.40 was similar to that observed in normotensive animals. In the anesthetized rat, angiotensin II evidently contributes to the maintenance of the rate of proximal fluid reabsorption. The magnitude of the angiotensin-stimulated component of proximal fluid absorption is similar in normotensive and 2-kidney, 1-clip Goldblatt hypertensive rats.