Metabolism of clebopride in vitro. Mass spectrometry and identification of products of amide hydrolysis andN-debenzylation
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 10 (3) , 211-218
- https://doi.org/10.3109/00498258009033747
Abstract
1. Electron impact and field desorption mass spectrometry is described and discussed for clebopride, a newly developed benzamide with anti-emetic and anti-dopaminergic properties, and for some related compounds. 2. When clebopride was incubated with liver homogenates of rabbits, 4-amino-5-chloro-2-methoxybenzoic acid and N-(4′-piperidyl)-4-amino-5-chloro-5-methoxy-benzamide were identified as metabolites.This publication has 23 references indexed in Scilit:
- Rapid thin-layer chromatographic photodensitometric method for the determination of metoclopramide and clebopride in the presence of some of their metabolic productsJournal of Chromatography A, 1979
- A comparison of in vitro and in vivo dopamine receptor antagonism produced by substituted benzamide drugsJournal of Pharmacy and Pharmacology, 1978
- Substituted benzamides as cerebral dopamine antagonists in rodentsNeuropharmacology, 1977
- Identification of Four New Metabolic Products of Metoclopramide using Mass SpectrometryXenobiotica, 1976
- Field Desorption Mass SpectrometryAngewandte Chemie International Edition in English, 1975
- Field Desorption Mass Spectrometry of Azathioprine and its MetabolitesJournal of Pharmaceutical Sciences, 1974
- The Identification of Four Metabolic Products after Incubation of p -Methoxyamphetamine with Liver Preparations of Various SpeciesXenobiotica, 1974
- Metabolic Oxidation of Aliphatic Basic Nitrogen Atoms and their α-Carbon AtomsXenobiotica, 1971
- BiotransformationsPublished by Royal Society of Chemistry (RSC) ,1970
- Field desorption mass spectrometry: A technique for the study of thermally unstable substances of low volatilityInternational Journal of Mass Spectrometry and Ion Physics, 1969