1-Carboranyl-3-(2-methylaziridino)-2-propanol. Synthesis, selective uptake by B-16 melanoma, and selective cytotoxicity toward cancer cells
- 1 July 1993
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 36 (15) , 2232-2234
- https://doi.org/10.1021/jm00067a021
Abstract
1-Carboranyl-3-(2-methylaziridino)-2-propanol (MACB) was prepared from the reaction of 1-carboranyl-2,3-epoxypropane with metalated methylaziridines having copper [Cu(CN)Li2]1/2 or lead (PbBu3) as the metal. MACB exhibited relatively high growth inhibition toward some cancer cells, and selective uptake of MACB by B-16 melanoma was accomplished.Keywords
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