PULMONARY FUNCTION IN PULMONARY HYPERTENSION

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Abstract
Twenty-seven patients (of whom 17 had congenital heart disease) with increased pulmonary vascular resistance were subjected to pulmonary function studies at rest and after exercise. In general, patients with pulmonary hypertension showed a variable reduction in lung compliance, diffusing capacity and ventilation equivalent for O2 and a slight increase in inspiratory resistance. No direct relationship between the level of pulmonary vascular resistance and the degree of disturbance of pulmonary function was noted. It is, therefore, felt that the changes described above may result from associated lung disease, mitral valve disease, or the effects of local thrombosis or embolism in different parts of the lungs.