Abstract
Cheilitis granulomatosa is a rare condition that has traditionally proved difficult to treat satisfactorily. Excellent results were obtained with local triamcinolone acetonide injections and surgery. Histopathologic features of the classic, untreated condition were reviewed and compared to the histopathologic features of labial tissues after a series of triamcinolone injections. The injected medication was effective in achieving some reduction of labial volume, apparently through a necrotizing effect on granulomas with subsequent replacement of fibrous scars. Discontinuation of local injections after initial surgery apparently contributed to an exacerbation, as shown by the histopathology of a 2nd cheiloplastic procedure. Patients with cheilitis granulomatosa who are receiving combined triamcinolonesurgical therapy should continue to receive local triamcinolone injections after surgery to minimize the tendency for recurrence.

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