BK Virus Infection in Hematopoietic Stem Cell Transplant Recipients: Frequency, Risk Factors, and Association with Postengraftment Hemorrhagic Cystitis
Open Access
- 15 December 2004
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 39 (12) , 1861-1865
- https://doi.org/10.1086/426140
Abstract
Blood samples from 132 consecutive hematopoietic stem cell transplant recipients were obtained and tested weekly for BK virus DNA by use of quantitative real-time PCR. Forty-four patients (33%) developed BK viremia at a median of 41 days (range, 9–91 days) after transplantation. Patients with hemorrhagic cystitis that occurred after platelet engraftment had higher levels of viremia than did patients without hemorrhagic cystitis (median, 9.7 × 103vs. 0 copies/mL; P = .008) and patients with hemorrhagic cystitis that occurred before platelet engraftment (median, 9.7 × 103vs. 0 copies/mL; P = .0006). BK viremia also was strongly associated with postengraftment hemorrhagic cystitis in a time-dependent analysis (P = .004).Keywords
This publication has 11 references indexed in Scilit:
- Optimization of Quantitative Detection of Cytomegalovirus DNA in Plasma by Real-Time PCRJournal of Clinical Microbiology, 2004
- Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated diseaseBlood, 2003
- 2002 Update of Recommendations for the Use of Chemotherapy and Radiotherapy Protectants: Clinical Practice Guidelines of the American Society of Clinical OncologyJournal of Clinical Oncology, 2002
- Clinicopathological features and risk factors of clinically overt haemorrhagic cystitis complicating bone marrow transplantationBone Marrow Transplantation, 2002
- Effect of Antivirals on Human Herpesvirus 6 Replication in Hematopoietic Stem Cell Transplant RecipientsClinical Infectious Diseases, 2002
- Quantitation of BK Virus Load in Serum for the Diagnosis of BK Virus–Associated Nephropathy in Renal Transplant RecipientsThe Journal of Infectious Diseases, 2001
- Testing for Polyomavirus Type BK DNA in Plasma to Identify Renal-Allograft Recipients with Viral NephropathyNew England Journal of Medicine, 2000
- EARLY DIAGNOSIS OF HUMAN CYTOMEGALOVIRUS DISEASE IN TRANSPLANT RECIPIENTS BY DNA AMPLIFICATION IN PLASMATransplantation, 1993
- LATE-ONSET HEMORRHAGIC CYSTITIS ASSOCIATED WITH URINARY EXCRETION OF POLYOMA VIRUSES AFTER BONE MARROW TRANSPLANTATIONTransplantation, 1987
- Association of BK Viruria with Hemorrhagic Cystitis in Recipients of Bone Marrow TransplantsNew England Journal of Medicine, 1986