Experimental assessment of the detection limit of genomic amplification by comparative genomic hybridization CGH
- 1 January 1997
- journal article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 78 (1) , 65-68
- https://doi.org/10.1159/000134632
Abstract
Artificial amplicons of known size, constructed by use of YACs featuring human 8p12 and 12q13, were analyzed by comparative genomic hybridization (CGH). A minimum of 15 Mb of overrepresented DNA sequences could be detected. The sensitivity is (1) not dependent on the chromosome site and (2) related to the size of the amplicon, decreasing with decreasing size.Keywords
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