CLOT RETRACTION FACILITATES CLOT LYSIS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 57  (1) , 44-48
Abstract
Platelet facilitation of clot lysis was studied using the dilute clot lysis assay, a standardized fibrinolysis assay shown to correlate with postoperative deep vein thrombosis development. Clots prepared from dilute platelet poor [human] plasma showed prolonged clot lysis when compared with clots prepared in a similar fashion from dilute platelet rich plasma. Since in platelet presence clot retraction or contraction occurred, a possible direct contribution of retraction to clot lysis was evaluated. Dilute platelet poor plasma clots were compacted by centrifugation, to a similar extent as that achieved during clot retraction in dilute platelet rich plasma. These clots now lysed at a rate that approached that seen with dilute platelet rich plasma clots. Using an alternate approach, dilute platelet rich plasma clots were treated with cytochalasin B to prevent clot retraction. Such clots now showed prolonged lysis similar to that seen with dilute platelet poor plasma. The prolonged lysis of cytochalasin B treated dilute platelet rich plasma clots was corrected by artificial clot compaction. Apparently clot retraction markedly facilitates clot lysis, and shows that a major platelet role to facilitate clot lysis is the effect of these cells to cause clot retraction.

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