Granulomatous Pulmonary Disease Secondary to Alternaria

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Abstract
THE Alternaria genus of fungi is ubiquitous in nature and is encountered frequently in the clinical laboratory in the form of airborne contaminants of cultures and microscopic preparations. Only rarely has Alternaria been associated with human disease. It has been implicated as a noninvasive stimulus for hypersensitivity pneumonitis1 and as an invasive pathogen in superficial infections of skin and nails.2 Most recently, a case report described maxillary osteomyelitis caused by Alternaria sp.3 This report describes a case of localized pulmonary granulomas due to Alternaria sp. The organism was recovered in pure culture from tissue, and morphologically compatible organisms were simultaneously identified in histologic sections. Review of the literature suggests that this represents the first report of true pulmonary pathogenicity secondary to Alternaria sp. Report of a Case A 36-year-old man was referred to Wilford Hall US Air Force Medical Center in May 1977 with chief complaints of

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