Abstract
Coronary heart disease is the major public health problem in the United States and in many other countries. In 1970, for example, some 666,000 Americans, of whom about 171,000 were under the age of 65, died of coronary heart disease (CHD) and many more were disabled by the same disorder. It is particularly disturbing that many relatively young Americans in their most productive years are killed or incapacitated by this disease. Epidemiologic, experimental, and clinical investigations have identified a number of "risk factors" associated with susceptibility to CHD that can be manipulated. These include an elevation in plasma lipids, especially plasma cholesterol, high blood pressure (hypertension), heavy cigarette smoking, obesity, and physical inactivity. The evidence is not sufficient to quantitate the benefits that may be expected to come from modifying these various risk factors, but the seriousness of the situation demands that all reasonable means be used to reduce the

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