At Issue: An Un-Dopamine Hypothesis of Schizophrenia
- 1 January 1980
- journal article
- Published by Oxford University Press (OUP) in Schizophrenia Bulletin
- Vol. 6 (3) , 387-390
- https://doi.org/10.1093/schbul/6.3.387
Abstract
The dopamine hypothesis of schizophrenia is examined critically. Although the hypothesis is couched in chemical terms, the evidence is primarily pharmacologic. In addition, neuroleptic mechanisms do not fit a simple hyperdopaminergic formulation, and treatment efficacy points to a general psychotic rather than specific schizophrenic role for dopamine. Most compromising to the hypothesis is the therapeutic action of L-dopa when combined with neuroleptics in chronic schizophrenics. Dopamine appears important but cannot be viewed as a simple pathogen.Keywords
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