Haplotype blocks and linkage disequilibrium in the human genome
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- 1 August 2003
- journal article
- review article
- Published by Springer Nature in Nature Reviews Genetics
- Vol. 4 (8) , 587-597
- https://doi.org/10.1038/nrg1123
Abstract
There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans and other species. Characterizing LD is of central importance for gene-mapping studies and can provide insights into the biology of recombination and human demographic history. Here, we review recent developments in this field, including the recently proposed 'haplotype-block' model of LD. We describe some of the recent data in detail and compare the observed patterns to those seen in simulations.Keywords
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