IMMUNOLOGICAL EFFECTS OF 1-ALPHA-HYDROXYCHOLECALCIFEROL (1-ALPHA-OH-D3) AND ITS METABOLITES

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 16  (3) , 119-125
Abstract
An immunosuppressive substance was detected in the serum and plasma of hemodialysis patients. There was a marked increase in its activity immediately after hemodialysis. This substance was not detected in the plasma of hemodialysis patients treated with 1.alpha.-hydroxycholecalciferol (1.alpha.-OH-D3), although its disappearance was unrelated to either the total dose or the duration of treatment with 1.alpha.-OH-D3. During in vitro studies, 1.alpha.-OH-D did not change the phytohemagglutinin-, staphage lysate- and concanavalin A-induced and spontaneous lymphoproliferation of peripheral blood lymphocytes (PBL) from a healthy person. Addition of 1.alpha.-OH-D3 to the plasma of hemodialysis patients who had not received 1.alpha.-OH-D3 did not interfere with the suppressive activity. 1.alpha.,24(R)-dihydroxycholecalciferol, 1.alpha.,24(S)-dihydroxycholecalciferol and 1.alpha.,25-dihydroxycholecalciferol, which are all metabolites of 1.alpha.-OH-D3, suppressed mitogen-induced lymphoproliferation of PBL from a healthy person.