Pleiotropy and the Preservation of Perfection
- 20 February 1998
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 279 (5354) , 1210-1213
- https://doi.org/10.1126/science.279.5354.1210
Abstract
A mathematical model is presented in which a single mutation can affect multiple phenotypic characters, each of which is subject to stabilizing selection. A wide range of mutations is allowed, including ones that produce extremely small phenotypic changes. The analysis shows that, when three or more characters are affected by each mutation, a single optimal genetic sequence may become common. This result provides a hypothesis to explain the low levels of variation and low rates of substitution that are observed at some loci.Keywords
This publication has 28 references indexed in Scilit:
- Small Population Genetic Variability at Loci Under Stabilizing SelectionEvolution, 1992
- Determinants of DNA sequence divergence betweenEscherichia coli andSalmonella typhimurium: Codon usage, map position, and concerted evolutionJournal of Molecular Evolution, 1991
- Variation maintained in quantitative traits with mutation–selection balance: pleiotropic side-effects on fitness traitsProceedings Of The Royal Society B-Biological Sciences, 1990
- EVOLUTIONARY QUANTITATIVE GENETICS: HOW LITTLE DO WE KNOW?Annual Review of Genetics, 1989
- Relative roles of mutation and selection in the maintenance of genetic variabilityPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1988
- Consequences of stabilising selection for polygenic variationHeredity, 1987
- Genetic Variation and Phenotypic Evolution During Allopatric SpeciationThe American Naturalist, 1980
- The maintenance of genetic variability by mutation in a polygenic character with linked lociGenetics Research, 1975
- The genetic variability of polygenic characters under optimizing selection, mutation and driftGenetics Research, 1972
- Pleiotropic Gene ActionEvolution, 1952