Stereospecific opiate binding in human erythrocyte membranes and changes in heroin addicts
- 1 January 1976
- journal article
- research article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 2 (5-6) , 427-431
- https://doi.org/10.1002/jnr.490020511
Abstract
Stereospecific opiate binding has been demonstrated in human erythrocyte membranes, having a Kd of 9 · 10–9 M. In most respects the binding characteristics resemble those of snyaptic membranes. These included the correlation of binding affinity and pharmacological potency of opiates; competition by naloxone; inhibition by Ca2+ and Na+; and sensitivity to phospholipases and tryspin. A comparison of stereospecific opiate binding in control human subjects and heroin addicts revealed a 43% increase in the addict group.Keywords
This publication has 9 references indexed in Scilit:
- Enhancement of stereospecific opiate binding to neural membranes by phosphatidyl serineEuropean Journal of Pharmacology, 1976
- Opiate receptor binding—enhancement by opiate administration in vivoBiochemical Pharmacology, 1976
- Stereospecific morphine adsorption to phosphatidyl serine and other membranous components of brainEuropean Journal of Pharmacology, 1975
- Identification of novel high affinity opiate receptor binding in rat brainNature, 1975
- Biological Membranes as Bilayer Couples. A Molecular Mechanism of Drug-Erythrocyte InteractionsProceedings of the National Academy of Sciences, 1974
- Properties of Opiate-Receptor Binding in Rat BrainProceedings of the National Academy of Sciences, 1973
- Stereospecific Binding of the Potent Narcotic Analgesic [ 3 H]Etorphine to Rat-Brain HomogenateProceedings of the National Academy of Sciences, 1973
- Stereospecific and Nonspecific Interactions of the Morphine Congener Levorphanol in Subcellular Fractions of Mouse BrainProceedings of the National Academy of Sciences, 1971
- Relation between the ability of various compounds to block nervous conduction and their penetration into a monomolecular layer of nerve-tissue lipoidsBiochimica et Biophysica Acta, 1958