Stimulation of Erythropoietic Differentiation in BALB/c Mice Infected With Rauscher Leukemia Virus23

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Abstract
The function of phenylhydrazine (PHZ) hemolysis in ameliorating the anemia Induced in mice by a slow-acting strain of Rauscher leukemia virus (RLY-A) was described. After cessation of treatment with PHZ, mid-stage RLV-A-infected, anemic mice responded with massive reticulocytoses and a rebound in hematocrit above control levels. RLY-infected mice, subjected to PHZ-induced hemolysis or phlebotomy, produced high levels of plasma erythropoietin (Ep); this suggested that Ep mediated the PHZ-induced differentiation. In addition, administration of exogenous Ep induced a wave of erythroid maturation in RLV-infected anemic mice, which indicated that virus-infected erythroid precursors could still respond to the hormone governing normal differentiation.

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