Activator of Plasminogen and Protease from Various Cell Cultures and Present in Poliomyelitis Vaccine

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Abstract
Assays of 25 metabolizing cell culture lines disclosed that 13 of these released an activator of plasminogen resembling tissue activator. Of 4 primary cell lines tested the 3 of kidney origin produced both activator and protease. Assay of a specific cell culture fluid, commercially prepared poliomyelitis vaccine, disclosed the presence of both activator and protease in many lots of vaccine.

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