Characterization of Low- and Very-Low-Density Hepatitis C Virus RNA-Containing Particles
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Open Access
- 15 July 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (14) , 7040-7048
- https://doi.org/10.1128/jvi.76.14.6919-6928.2002
Abstract
The possible biochemical factors able to affect the in vitro expression of the high-risk human papillomavirus type 16 (HPV16) E7 oncoprotein have been analyzed. Evidence is provided that E7 mRNA stability is increased and, conversely, transcript translation is inhibited by binding to a 32-kDa protein from rabbit reticulocyte lysate; sequence analysis identified the 32-kDa binding protein as rabbit α1-globin protein; and interaction between rabbit α1-globin and E7 mRNA occurs through the 6-mer peptide SEQIKA present in human cytokeratin 7 protein. The in vitro data were confirmed by the occurrence of HPV16 E7 mRNA-cytokeratin 7 binding in squamous cervical cancer SiHa cells.Keywords
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