DIRECT INDUCTION OF MHC CLASS I, BUT NOT CLASS II, EXPRESSION ON ENDOTHELIAL CELLS BY CYTOMEGALOVIRUS INFECTION

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Abstract
MHC expression on endothelial cells after cytomeg-alovirus infection was investigated using double antibody radioimmunoassays and immunofluorescence flow cytometry. After CMV infection there was an increase in class I and 02 microglobulin expression. This increase corresponds to the percentage of cells that are infected with CMV. There was no evidence that the increased class I expression was due to soluble factors produced by the infected cells. Although CMV only affects approximately 10% of the endothelial cells, class I and β2 microglobulin expression on the cell population exceeds that induced by an optimal dose of alpha-interferon. Class II expression is not increased after CMV infection. However, when gamma-interferon was added to the medium after CMV infection a normal increase in class II expression was found, suggesting that CMV infection does not inhibit the gamma-interferon—induced expression of these molecules.

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