The Wellcome Trust Lecture: Inflammatory responses to filarial connective tissue parasites
- 1 January 1987
- journal article
- review article
- Published by Cambridge University Press (CUP) in Parasitology
- Vol. 94 (S1) , S101-S122
- https://doi.org/10.1017/s003118200008584x
Abstract
SUMMARY: The inflammatory responses to lymphatic filariae and toOnchocerca volvulusare reviewed with particular attention to (1) evolutionary biology; (2) inflammatory host spectrum; (3) non-specific components; (4) immunoregulation; (5) immune evasion versus immunomodulation; (6) chronic tissue damage and scarring and (7) disease models. Basic principles of pathogenesis are emphasized, comparisons drawn with schistosome infection, and critical items of missing information are highlighted.Keywords
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