Feasibility Studies on Radiation Sterilization of Cephradine
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 16 (10) , 1661-1673
- https://doi.org/10.3109/03639049009025778
Abstract
A comprehensive study was carried out to examine and evaluate the feasibility of radiation sterilization of cephradine antibiotic in the solid dry state. Absorbed gamma ray doses in the range of 5–25 kGy caused a dose-dependent loss of bactericidal activity. Moreover, radiation caused a dose-dependent degradation of the antibiotic and decrease in cephradine content due to radiation conversion to cephalexin. The former deleterious effect was detected spectrophotometrically and confirmed by high-performance liquid chromatography (HPLC). The latter effect was detected by NMR spectroscopy and by HPLC. The study revealed a noticeable change in the tint of the irradiated powdered drug which is dose-dependent and clearly remarkable at high radiation doses.This publication has 4 references indexed in Scilit:
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- Einwirkung von Gamma‐ und Neutronen‐Strahlung auf ArzneistoffeArchiv der Pharmazie, 1973
- Radiation Sterilization of Foods, Comparison of the Radiosensitivities of the Fat-Soluble Vitamins by Gamma IrradiationJournal of Agricultural and Food Chemistry, 1961
- The Effect of Gamma Radiation on Some Pharmaceutical Products*Journal of the American Pharmaceutical Association (Scientific ed.), 1954