Protein Synthesis in Vitamin B6 Deficiency in the Rat

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Abstract
Young rats were divided into three groups of the same average body weight. Those of one group were deprived of vitamin B6. The other two groups served as controls. The animals of one control group were fed the same amount of food as those deprived of the vitamin. Those of the other were maintained at the same rate of growth as the vitamin-deprived animals by restriction of their food intake. After 65 days, when growth had been significantly impaired by the vitamin deficiency, the protein content of the diet of all animals was adjusted to subject them to successive periods of protein depletion and repletion. At each stage of this regimen the protein and nonprotein nitrogen of the liver and blood plasma were determined on animals from each of the three groups. Vitamin B6 deficiency was not associated at any stage with significant differences among the three groups in the size of the liver, or the concentration of protein in it or in the blood plasma. There was apparently no impairment of the anabolic processes involved in the synthesis of these proteins.

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