Chromosome aberrations induced by protons up to 31 MeV in cultured human cells

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Abstract
Chromosome aberrations were induced in cultured human cells by proton beams of 31, 12, and 8 MeV. The frequencies of isocromatid breaks and dicentrics have been analysed as a function of proton energy and dose. Both effects are largely dependent on proton energy; isochromatid breaks increase linearly with the dose, whereas dicentrics show a definite parabolic behaviour. The experimental data were fitted to the analytic formY = KD n andY = αD +βD 2 and the best fitted values of the parameters are reported and discussed. The values of RBE for the isochromatid breaks are in the ratio 1.7: 1.3: 1 for 8, 12, and 31 MeV respectively. In the case of the dicentrics the RBE values are dose-dependent function of the typeCD −n . The three distributions of dicentrics among the cells do not fit a Poisson distribution.

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