A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells.
- 1 January 1988
- journal article
- Vol. 7 (1) , 29-35
Abstract
Zinc fingers are DNA-binding domains present in several eukaryotic regulatory proteins. We have identified a mouse gene, Krox-20, encoding a protein with three zinc fingers and whose expression is activated during G0/G1 transition in cultured cells. Serum stimulation of quiescent cells leads to rapid and transient accumulation of Krox-20 mRNA, with kinetics similar to those of the c-fos proto-oncogene. The induction does not require de-novo protein synthesis. In the mouse, Krox-20 is expressed at low levels in tissues which contain rapidly dividing cells. These properties suggest that Krox-20 encodes a transcription control factor, possibly involved in the modulation of cell proliferation.This publication has 63 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cellsJournal of Molecular Biology, 1987
- Two zinc fingers of a yeast regulatory protein shown by genetic evidence to be essential for its functionNature, 1987
- Bombesin induces c-fos and c-myc expression in quiescent Swiss 3T3 cellsExperimental Cell Research, 1987
- V-Fos stimulates expression of the α1(III) collagen gene in NIH 3T3 cellsBiochemical and Biophysical Research Communications, 1986
- Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomesCell, 1986
- The primary structure of transcription factor TFIIIA has 12 consecutive repeatsFEBS Letters, 1985
- Induction of c-fos gene and protein by growth factors precedes activation of c-mycNature, 1984
- Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and proteinNature, 1984
- Coding potential and regulatory signals of the polyoma virus genomeNature, 1980