Studies of the Sal I Strain of Plasmodium vivax in the Squirrel Monkey (Saimiri sciureus)

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Abstract
The Sal I strain of P. vivax was successfully adapted to 3 phenotypes of the squirrel monkey, S. sciureus. Through 5 linear blood passages, parasitemias in excess of 200,000/mm3 blood were attained; Bolivian phenotype Saimiri appear to develop higher peak parasitemias. Sporozoites of the Sal I strain inoculated i.v. proudced patent parasitemias in all 5 squirrel monkeys challenged, with prepatent periods ranging from 21 to 38 days. Anopheles freeborni and A. gambiae were the most susceptible of 8 anopheline species [A. freeborni, A. gambiae, A. culicifacies, A. albimanus, A. stephensi, A. quadrimaculatus, A. dirus and A. maculatus] fed on infected squirrel monkeys. As a model for an invo studies of P. vivax the Sal I strain in Saimiri has great potential.

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