Humoral and cellular response to infection withEchinostoma revolutumin the golden hamster,Mesocricetus auratus

Publisher Website
Google Scholar
Abstract
Laboratory hamsters (Mesocricetus auratus) were infected withEchinostoma revolutum(Trematoda). Immunoelectrophoretic studies of hamster serum showed no demonstrable antibody response toE. revolutum. Histopathologic examination of intestinal tissue of infected hamsters showed erosion of intestinal villi and lymphocytic infiltration as the primary host response. Spleens from infected hamsters were hyperplastic during the first 3 weeks of infection and atrophic from 4 to 8 weeks postinfection. Hamsters were unable to acquire a resistance toE. revolutuminfection. Lack of resistance was demonstrated in hamsters where the parasite infection was no longer detected based on the absence of eggs in the faeces; these hamsters were then reinfected. Hamsters treated with the anthelmintic oxyclozanide were also reinfected withE. revolutum.