This is the third edition of this book to appear in eight years, the first appearing in 1936. The author has made some changes in this edition. They consist essentially of dividing the data into more chapters for emphasis and the inclusion of four new chapters dealing with psychogenic disturbances associated with heart disease, essential hypertension and disturbances in blood pressure and general systemic types of heart disease. Since the handbook is intended for the use of students, who are in need of "succinct outlines," the reviewer is impressed by certain aspects of the presentation which fail in these objectives. There is a great tendency for repetition, which is surely not intended for emphasis. For example, on page 437 are found the following statements concerning the histamine test: "In a few minutes there normally develops a red spot which rises into a 1 cm. wheal surrounded by flares 2 cm.