A RE‐EVALUATION OF ACETYLCHOLINE RECEPTORS ON FELINE RENSHAW CELLS
Open Access
- 1 June 1981
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 73 (2) , 455-460
- https://doi.org/10.1111/j.1476-5381.1981.tb10442.x
Abstract
1 The effects of atropine, methylatropine and lachesine administered by ionophoresis were examined on responses of Renshaw cells to acetylcholine, acetyl-β-methylcholine, nicotine and DL-muscarine in cats anaesthetized with pentobarbitone or chloralose. 2 The antagonists were as effective in antagonizing excitation by nicotine as they were in antagonizing excitation by acetylcholine and were only slightly more effective in antagonizing excitation by acetyl-β-methylcholine. 3 These results are discussed in relation to the characterization of acetylcholine receptors on Renshaw cells. 4 It is concluded that there are two distinct populations of receptors but that the nicotinic receptors are non-selective in their activation by agonists and antagonists, whereas the muscarinic receptors display greater selectivity.Keywords
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