My attention was recently attracted to the subject of managanese poisoning when I was consulted by a patient who was suffering with a malady, the clinical picture of which was not at all familiar to me. The condition was obviously the result of a disease of the central nervous system, but it fitted no classic picture of a well recognized syndrome. In view of the fact that the patient had worked for several months in a manganese grinding plant, the possibility of manganese poisoning was considered. The descriptions available of this disease agreed so well with the subjective and objective symptoms of the patient under consideration that this diagnosis was made, but with some hesitation. Later, the wife of the patient volunteered the information that she knew of several other workers in the same manganese grinding plant who suffered similarly. Forthwith, a trip was made to the neighborhood of this