The gene and the pseudogene for mouse p53 cellular tumor antigen are located on different chromosomes.
Open Access
- 1 August 1984
- journal article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 4 (8) , 1638-1640
- https://doi.org/10.1128/mcb.4.8.1638
Abstract
The chromosomal assignments of the two genes encoding the murine p53 cellular tumor antigen were determined by using a panel of mouse-Chinese hamster somatic cell hybrid clones and a mouse p53-specific cDNA clone. One gene, probably the functional member of the family, was found to be on chromosome 11. The other gene, which is probably a processed pseudogene, was assigned to chromosome 14. The potential relevance of these findings to documented cases of chromosome 11 trisomy are also discussed.Keywords
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