β‐Amyloid Fragment 25–35 Selectively Damages Platelets from Patients with Alzheimer's Disease
- 1 November 2002
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 977 (1) , 296-302
- https://doi.org/10.1111/j.1749-6632.2002.tb04829.x
Abstract
In order to analyze the metabolic response of AD patient platelets to beta-amyloid, we have carried out fluorimetric measurements of intracellular calcium and an ultrastructural survey of platelets exposed to the beta-amyloid active fragment 25-35 (betaA(25-35)). Since it is not possible to analyze directly the damaged neurons in AD, the study of peripheral blood cells, especially platelets, may be of great value for the investigation of the toxic effects of beta-amyloid on AD neuronal cells.Keywords
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