The Role of N-Methyl-d-Aspartate (NMDA) Receptors in Pain: A Review
Top Cited Papers
- 1 October 2003
- journal article
- review article
- Published by Wolters Kluwer Health in Anesthesia & Analgesia
- Vol. 97 (4) , 1108-1116
- https://doi.org/10.1213/01.ane.0000081061.12235.55
Abstract
There is accumulating evidence to implicate the importance of N-methyl-d-aspartate (NMDA) receptors to the induction and maintenance of central sensitization during pain states. However, NMDA receptors may also mediate peripheral sensitization and visceral pain. NMDA receptors are composed of NR1, NKeywords
This publication has 78 references indexed in Scilit:
- Motoneuron-Specific Expression of NR3B, a Novel NMDA-Type Glutamate Receptor Subunit That Works in a Dominant-Negative MannerJournal of Neuroscience, 2001
- NMDA receptor antagonists as analgesics: focus on the NR2B subtypePublished by Elsevier ,2001
- NMDA receptor subunits: diversity, development and diseaseCurrent Opinion in Neurobiology, 2001
- Subunit- and site-specific pharmacology of the NMDA receptor channelProgress in Neurobiology, 1999
- Molecular Determinants of Agonist Discrimination by NMDA Receptor Subunits: Analysis of the Glutamate Binding Site on the NR2B SubunitNeuron, 1997
- The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region.Proceedings of the National Academy of Sciences, 1996
- Structure and function of the NMDA receptor channelNeuropharmacology, 1995
- Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brainJournal of Neuroscience, 1995
- Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the ratBrain Research, 1987
- Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.Neuropharmacology, 1987