PRESERVATION OF ISCHEMIC RAT-LIVER MITOCHONDRIAL FUNCTIONS AND LIVER VIABILITY WITH COQ10

  • 1 January 1982
    • journal article
    • research article
    • Vol. 91  (6) , 631-637
Abstract
The present study was undertaken to determine whether Co[coenzyme]Q10 administration to rats can protect hepatic mitochondrial function, improve energy metabolism during hepatic ischemia and subsequent reperfusion, and prolong the viability of the organ. Although ischemia of the liver for 90 min did not permit survival of the animals, CoQ10 administration (6 mg/kg of body wt) increased the survival rate to 60%. The period of ischemia was accompanied by decreases in hepatic ATP level and respiratory control index without significant increases in mitochondrial Ca content and lipid peroxide formation, The subsequent restoration of blood flow resulted in a low recovery of ATP level, recovery of respiratory control and ADP:O ratio to levels significantly lower than normal, and marked increases in mitochondrial Ca and lipid peroxide levels. In CoQ10-treated animals mitochondrial functions were all completely reversible and resynthesis of ATP was accelerated even after 90 min of ischemia. The pretreatment also completely suppressed the elevation of mitochondrial Ca and lipid peroxide levels. Preservation with CoQ10 of cellular damages caused by hepatic ischemia is probably due to protection of cellular and subcellular membranes from lipid peroxidation, so that mitochondrial functions are restored and cellular Ca homeostasis is maintained.

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