Intramolecular Hydrogen Bonding in Bilirubin Bis-Tetra-n-butyl Ammonium Salts as Determined by1H-NMR Spectroscopy

Abstract
Analysis of the N-H 1H-NMR chemical shifts of the bis-pro-pionate ions of bilirubin IXα and XIIIα reveals a preference in CDCl3 and d6-DMSO for folded conformations in which the propionate groups are intramolecularly H-bonded to the opposing pyrromethenone units.

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