Photochemical Transformation of 5-Alkyluracils and Their Nucleosides
- 30 July 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 173 (3995) , 435-437
- https://doi.org/10.1126/science.173.3995.435
Abstract
Irradiation at 254 nm of aqueous solutions of 5-ethyl-, 5-propyl-, and 5-isopropyluracils (or their nulcleosides) leads to cleavage of the 5-alkyl substituents, via an intramolecular electrocyclic photoaddition intermediate, with formation of uracil (or its nucleoside). The plhotoaddition intermediates represent a new class of dihydropyrimidines, namely analogs of 5,6-dihydro-5,6-cyclobutanyluracil and its nucleosides; the biological significance is discussed.Keywords
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