DEVELOPMENT OF ADENOCARCINOMA OF PROSTATE IN ICR MICE LOCALLY IRRADIATED WITH X-RAYS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 67  (3) , 407-411
Abstract
The pelvic region of male ICR/JCL mice 5.apprx.7 wk of age was irradiated with 1000 rads of X-ray for a total of 8 exposures to determine whether such irradiation would induce prostatic carcinoma. Prostatic adenocarcinoma was observed in 5 of 135 animals which survived more than 12 wk after the 1st X-irradiation. Because spontaneous development of prostatic adenocarcinoma was not reported in mice, development of this carcinoma in these animals can be attributable to X-irradiation.