Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation
Open Access
- 20 January 2004
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 18 (3) , 469-479
- https://doi.org/10.1096/fj.03-0699com
Abstract
Fibroblast proliferation, differentiation into myofibroblasts, and increased collagen synthesis are key events during both normal wound repair and fibrotic lesion formation. Here we report that these...Keywords
Funding Information
- National Institutes of Health (GM 37223, GM 65603)
This publication has 65 references indexed in Scilit:
- Role of CTGF/HCS24/ecogenin in skeletal growth controlJournal of Cellular Physiology, 2003
- The α5β1 integrin selectively enhances epidermal growth factor signaling to the phosphatidylinositol-3-kinase/Akt pathway in intestinal epithelial cellsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2001
- The modular architecture of a new family of growth regulators related to connective tissue growth factorPublished by Wiley ,2001
- Transforming Growth Factor-β Overrides the Adhesion Requirement for Surface Expression of α5β1 Integrin in Normal Rat Kidney FibroblastsJournal of Biological Chemistry, 1999
- Transforming Growth Factor-β and Forskolin Increase All Classes of Insulin-like Growth Factor-I Transcripts in Normal Human Osteoblast-like CellsBiochemical and Biophysical Research Communications, 1995
- Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblastsThe Journal of cell biology, 1993
- The origin of pattern and polarity in the Drosophila embryoCell, 1992
- Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.The Journal of cell biology, 1991
- TGF-β inhibition of endothelial cell proliferation: Alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expressionCell, 1987
- Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.Journal of Histochemistry & Cytochemistry, 1981