The Catalytic Subunit of Telomerase Is Expressed in Developing Brain Neurons and Serves a Cell Survival-Promoting Function
- 1 January 2000
- journal article
- Published by Springer Nature in Journal of Molecular Neuroscience
- Vol. 14 (1-2) , 003-016
- https://doi.org/10.1385/jmn:14:1-2:003
Abstract
Telomerase, a specialized reverse transcriptase (RT) linked to cell immortalization and cancer, has been thought not to be expressed in postmitotic cells. We now report that telomerase activity and...Keywords
This publication has 41 references indexed in Scilit:
- Molecular interactions between telomerase and the tumor suppressor protein p53 in vitroOncogene, 1999
- Prostate Apoptosis Response‐4 Mediates Trophic Factor Withdrawal‐Induced Apoptosis of Hippocampal NeuronsJournal of Neurochemistry, 1999
- P53 Is Essential for Developmental Neuron Death as Regulated by the TrkA and p75 Neurotrophin ReceptorsThe Journal of cell biology, 1998
- Evidence for Synaptic ApoptosisExperimental Neurology, 1998
- Extension of Life-Span by Introduction of Telomerase into Normal Human CellsScience, 1998
- Telomere Reduction and Telomerase Inactivation during Neuronal Cell DifferentiationBiochemical and Biophysical Research Communications, 1996
- Telomeres, Telomerase and CancerScientific American, 1996
- Aging, energy, and oxidative stress in neurodegenerative diseasesAnnals of Neurology, 1995
- Specific Association of Human Telomerase Activity with Immortal Cells and CancerScience, 1994
- Biosynthesis of DNA and RNA in neuronal and glial cells from various regions of developing rat brainJournal of Neuroscience Research, 1976