Strahlenchemische Veränderung der 5-Halogen-Uracile in der DNS durch UV-Strahlen

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Abstract
After culture of Enterococcus Stei with Cl4-labeled 5-chlor-, 5-brom- or 5-iodine-uracil, desoxyribonucleic acid (DNA) was isolated from the cells and highly purified. The incorporated 5-halogen-uracils were photo-chemically changed by UV irradiation of these desoxyribonucleic acids in aqueous solution. After irradiation of the DNAs, uracil is the preponderant irradiation product found after decomposition and after fermentative degradation (uracildesoxyriboside). The dehalogenation of 5-bromo-uracil (BU) and 5-iodo-uracil (IU) in the DNA proceeds at the same rate, whereas 5-chlorouracil is dehalogenated much more slowly. The photochemical dehalogenation of BU occurs most easily in native DNA, less well in heat denatured DNA and only to a very small extent in apurinic acid.

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