Serum Factors Causing Abnormal Retardation of the Microelectrophoretic Mobility of the Red Blood Cell During Disease

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Abstract
Erythrocytes of healthy humans migrate at a constant mobility in an electric field. This mobility is retarded in a variety of nonmalignant diseases and almost invariably in malignant neoplasm. The serum of healthy persons contains a factor that will restore normal mobility to cells with retarded mobility. The serum from both malignant neoplasm and nonmalignant disease contains a factor that will retard the mobility of normally-migrating cells. The factor in the serum of malignant neoplastic disease can be differentiated from the factor in the serum of nonmalignant disease.

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