Effects ofOpuntia ficus-indica var.Saboten stem on Gastric damages in rats

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Abstract
The effects of the dried stem powder ofOpuntia ficus-indica var. saboten (OF-s) were investigated on gastric lesion and ulcer models in rats. It showed significant inhibition in HCI ethanol-induced gastric lesion at the doses of 200 and 600 mg/kg p.o. and in HCI aspirin-induced gastric lesion at 600 mg/kg p.o. OF-s also showed significant inhibition in indomethacin-induced gastric lesion at the doses of 200 and 600 mg/kg, p.o. However, it did not affect both the aspirin-induced and Shay ulcers in rats. It also did not affect gastric juice secretion, acid output and pH. These data indicate that OF-s only possesses pronounced inhibitory action on gastric lesion without antiulcer activity in rats.